Olfactory Receptor

Olfactory receptors (ORs) are a class of G protein-coupled receptors (GPCRs) located in the nasal olfactory epithelium, belonging to class A of GPCRs with seven transmembrane helix structures, primarily responsible for detecting odor molecules. These receptors initiate a series of signal transduction events by activating G proteins and generating cAMP, leading to the production of electrical signals in olfactory neurons, which are ultimately interpreted as specific smells by the brain. Humans encode about 400 types of olfactory receptors, divided into two major subfamilies: Class I and Class II olfactory receptors.
Olfactory receptors play roles in various diseases, including olfactory loss or disorders (such as temporary olfactory loss caused by colds or rhinitis), metabolic diseases (studies have shown that some olfactory receptors regulate glucose metabolism in diabetes and obesity), and cancer (abnormal expression of olfactory receptors is related to the development of various cancers, such as prostate cancer and breast cancer). These studies not only provide a deep understanding of the functions of the olfactory system but may also offer new strategies for researching related diseases^[1].

References:

[1]. Wu C, et al. The structure and function of olfactory receptors. Trends Pharmacol Sci. 2024 Mar;45(3):268-280. [Content Brief]

Olfactory Receptor Related Products (9):

By Effects:	Agonists (5) Ligand (1) Antagonist (1) Activator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N8847

α-Ionone	Activator
α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro.

HY-31962

Bourgeonal	Agonist	99.21%
Bourgeonal is a potent agonist of hOR17-4 and acts as a strong chemoattractant in sperm behavioral assays.

HY-186028

HOR1-C59	Agonist	99.89%
HOR1-C59 is a highly selective Or5v1/Olfr110 agonist with an EC₅₀ of 7.12 nM. HOR1-C59 can improve glucose homeostasis, alleviate obesity and insulin resistance. HOR1-C59 is applicable for obesity-related research.

HY-W721109

(R)-(-)-Muscone	Agonist	98.61%
(R)-(-)-Muscone, a musk-smelling compound, is an odorant receptor OR5AN1 agonist.

HY-116108

Musk tibetene	Ligand
Musk tibetene (Musk tibetine) is a nitro musk compound with carcinogenic activity. Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell line.

HY-145788

5-Cyclopropylpentanal	Agonist
5-Cyclopropylpentanal is an olfactory receptor agonist. 5-Cyclopropylpentanal enhance OR-I7 activation with an EC₅₀ of 0.3 μM.

HY-121787

OX1a	Antagonist
OX1a (OLC20) is an Orco antagonist with non-competitive activity that inhibits the activation of oxygen odor receptors (ORs). OX1a is able to reduce the activation of ORs by competitively inhibiting the effects of Orco agonists. OX1a also shows non-competitive inhibition of odor molecules, which may affect the olfactory-mediated behavior of insects. Through structural optimization, OX1a analogs have shown higher antagonistic potency, indicating that this type of compound may have application potential in a wide range of insect species.

HY-W097929

Tyrene
Tyrene (2,4,6-Trichloroanisole) is a the detoxification product of toxic 2,4,6-Trichlorophenol by filamentous fungi. Tyrene is the key substance that causes "cork taint" in wine. Tyrene can be used for the researches on food quality control and detoxification of environmental pollutants.

HY-W109323

(E)-8-Dodecenyl acetate	Agonist
(E)-8-Dodecenyl ((E)-8-Dodecen-1-yl; trans-8-Dodecenyl) acetate is a sex pheromone targeting the olfactory receptors of male Gymnandrosoma aurantianum moths. acting as an agonist. (E)-8-Dodecenyl acetate is promising for research of agricultural pests.

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